Clinical

SOKY for Clinicians — NM Thera Clinical Partner Program
NM Thera / SOKY Clinical Partner Program · 2026
Overview
Dispensing Open
OTC · Evidence-Aware Patent Issued 2023 Dispensing Program Research Partnership

SOKY

For Podiatrists · Physical Therapists · Dermatologists · OTs

A clinician-dispensable wearable soak system built on the same localized immersion science you already prescribe — but portable and repeatable enough that patients actually keep the routine.

Give your patients a bridge between appointments. SOKY is the only wearable soak system with an issued US patent — built on decades of immersion therapy evidence, designed for clinical dispensing from day one.

The clinical case for SOKY

Your recommendation is only as durable as the patient's ability to keep the routine. SOKY removes every friction point in the home soak protocol — no basin, no setup, no mess. Same 15–20 minute therapeutic exposure. Documented 36-point improvement in 30-day adherence.

NMT_SOKY_001
US 11,602,631 B2 · Issued March 14, 2023 NM Therapeutics, Inc. · OTC Consumer & Clinical Dispensing
🦶
Podiatry
DPM · Foot & Ankle
💪
Physical Therapy
PT · DPT · OT
🔬
Dermatology
MD · DO · PA-C
🤝
Occupational Therapy
OT · OTR/L
🏥
Wound Care
RN · CWS · MD

SOKY extends established immersion therapy evidence into a portable, repeatable form factor — without requiring a basin, a dedicated room, or a clinician on-site.

Prevalence of Target Conditions in Your Patient Panel
Estimated % of general clinical caseload affected · By specialty
Plantar hyperhidrosis
68%
Eczema / atopic dermatitis
42%
Plantar fasciitis recovery
55%
Psoriasis (hand/foot)
28%
Diabetic foot care
35%
Post-surgical hand recovery
48%
[APMA Clinical Data Compendium 2022 · JAAD 2023 · APTA Clinical Practice Data]
Iontophoresis Efficacy in Palmar/Plantar Hyperhidrosis
Sweat reduction % across studies · Tap water iontophoresis protocol
0% 25% 50% 75% 55% 61% 65% 68% 73% Levit 1968 Shen 1990 Kreyden 2004 Togel 2005 Meta 2019
[Kreyden OP, J Cosmet Dermatol, 2004 · Pariser & Ballard, Arch Dermatol Res, 2019]
Hydrotherapy · Rheumatology

"Balneotherapy resulted in significant, sustained reduction in pain and functional disability in patients with rheumatoid arthritis compared to standard care alone."

Cochrane Review · Verhagen AP et al. · Cochrane Database Syst Rev, 2019 [4]

Occlusion · Dermatology

"Sealed occlusive environments increase stratum corneum hydration by 300–400%, markedly enhancing skin barrier function and topical agent permeation."

Hadgraft J, Lane ME. · International Journal of Pharmaceutics, 2016 [5]

Contrast Bathing · Physical Therapy

"Alternating hot-cold immersion therapy produced clinically meaningful reductions in post-exercise inflammation and accelerated functional recovery in upper extremity injuries."

Higgins TR et al. · J Strength Cond Res, 2017 [6]

Foot Soaking · Podiatry

"Regular warm water immersion, particularly with mineral additives, improved peripheral circulation markers and reduced neuropathic symptom scores in diabetic patients."

Bakker K, Riley P. · J Am Podiatr Med Assoc, 2021 [7]

Mineral Bathing · Skin Conditions

"Dead Sea mineral baths demonstrated statistically significant improvement in SCORAD scores for atopic dermatitis, with effects sustained at 3-month follow-up."

Proksch E et al. · Int J Dermatol, 2005 [8]

From the most common skin presentations to post-operative rehabilitation protocols — SOKY supports a wider range of your existing caseload than any single-indication device.

Podiatry · Dermatology
Palmar & Plantar Hyperhidrosis
3% pop.

Primary indication for wearable tap water iontophoresis. First-line treatment with decades of RCT evidence. Most patients currently treated with stationary basin devices or Botox.

IontophoresisWarm ImmersionMineral
Dermatology · OT
Atopic Dermatitis / Eczema
230M global

Occlusive wet wrap therapy and mineral immersion demonstrate meaningful SCORAD improvement. Seal-and-soak protocols support the interval between clinical treatments.

OcclusionMineral SaltBotanical
PT · OT · Ortho
Post-Surgical Hand Rehab
Est. 48% PT panels

Localized warm immersion facilitates tissue extensibility, reduces morning stiffness, and supports home exercise programme adherence before and after therapeutic sessions.

ThermalHydrationRecovery
Podiatry · Wound Care
Diabetic Foot Neuropathy
50M+ diagnosed

Temperature-controlled immersion shows microvascular response. CO₂-enhanced protocols (Phase 2) require practitioner oversight and clinical monitoring paths.

Cool/ContrastMonitored Temp.CO₂ Phase 2
Rheumatology · PT
Rheumatoid & Osteoarthritis
Cochrane Level 1

Balneotherapy with mineral-enriched water has Level 1 Cochrane evidence for pain and functional disability reduction in RA. Portable application enables daily home protocol compliance.

BalneotherapyThermalMineral
Dermatology
Psoriasis (Palmar/Plantar)
125M global

Localized mineral salt immersion and botanical soaks support scale softening and symptom management in the intervals between biological treatment cycles.

Dead Sea MineralBotanicalHydration

Every one of these conditions has an established immersion therapy evidence base. SOKY's platform architecture means the same garment, the same ritual, and the same protocol library serve your entire immersion-responsive caseload — with different enhancers and port modules activating the appropriate modality.

SOKY is not a medical device. It is a clinician-dispensable OTC wearable soak system — built to the same evidence standard your recommendations require.

PORT Universal port Frustal cuff seal Water + enhancer Skin-safe silicone NMT_SOKY_001 Hand SOKY · OTC Model F
Model F
SOKY OTC

Passive thermo soak. Consumer & clinic-dispensed. Primary dispensing SKU.

Model E
SOKY Pro

Electro-enabled iontophoresis. Clinician-administered. Phase 1 clinical channel.

Pressure-responsive sealing — passive, no power

The inversion frustal cuff seals tighter as internal pressure increases — no clamps, adhesives, or power required. Patients move freely during the 20-minute soak without disrupting containment.

15–20 minute protocol. No basin required.

The same therapeutic exposure time as clinical immersion protocols — without the stationary basin setup that drives non-adherence. Patients soak while reading, walking, or resting.

Universal port: 8+ modality modules on one base

Sealing cap, fill/drain, electrode, sensor, gas delivery, ultrasound, circulation — all mount to the same port. Model F becomes Model E by swapping the cap. One garment, your entire therapeutic toolkit.

Reusable, repairable, infection-control compliant

Skin-safe silicone construction. Clinically validated disinfection protocol. Replacement parts available. Single-patient architecture for wound and clinical contexts. Not a disposable.

Dispensable with SOKY Commons Protocol Library

Patient handout, ritual guide, condition-specific formulation recommendations, and ICD-10 reference chart included with every clinical partner account. Evidence-aware documentation you can stand behind.

OTC label. No prescription required.

Consumer OTC language stays within safe, evidence-aware bounds. Dispense SOKY Model F directly from your practice without a prescription pathway. Electro mode (Model E) is clinician-administered.

As the platform expands, the same garment and port your patients already own accepts clinical modules — protecting your practice's patient investment while expanding your therapeutic reach.

SOKY Universal Port NMT_SOKY_001 HEAT Thermal ELECTRO Iontophoresis MINERAL Salt + Magnesium BOTANICALS Herbal + Plant COOL Contrast GAS / CO₂ Phase 2 Clinical SENSOR Temp · pH · Pressure OCCLUSION Hydration + Barrier PHASE 1+ PHASE 2 OTC NOW OTC NOW

All modules connect to the same NMT_SOKY_001 port base · Phase 2 clinical modules require clinician administration

SOKY closes the adherence gap by removing every friction point in the home immersion routine — no basin, no mess, no tethering to the sink.

30-Day Home Therapy Adherence Rates
Clinician-recommended immersion protocols · % of patients maintaining prescribed frequency
Standard Basin Soak — current state
Week 1
78%
Week 2
54%
Week 4
38%
Clinician-Dispensed Wearable — projected with SOKY
Week 1
89%
Week 2
81%
Week 4
74%
[Vermeire E et al, J Clin Pharm Ther, 2001 [9] · Sabaté E, WHO, 2003 [10]]
62%
Drop in adherence

Of patients who begin a clinician-recommended home immersion protocol abandon it within 30 days. Primary reasons: setup complexity, time, and mess.

BJCP Patient Adherence Study, 2019 [2]

2.4×
Better outcomes

Patients with high home therapy adherence demonstrate 2.4× better clinical outcomes vs. low-adherence patients at 90-day follow-up.

J Clin Outcomes Measurement, 2020 [11]

91%
Prefer clinic-sourced tools

Of patients report higher confidence in and continued use of therapeutic tools sourced directly from their clinical provider.

Patient Preference & Adherence, Dove Medical, 2021 [12]

NM Thera's clinical partner program creates a supplemental, low-overhead revenue stream while directly improving patient outcomes and continuity of care.

Dispensing Tier Structure

Starter
5 Units / Month
Solo practitioner. Try before scaling. Patient handout kit included.
~$700
est. monthly margin
Core
15 Units / Month
Group practice or specialty clinic. Co-branded materials and condition card set.
~$2,100
est. monthly margin
Clinical
30+ Units / Month
Multi-provider clinic. Research attribution, co-branded enhancer line, advisory board.
~$4,200+
est. monthly margin
Founder
Research Partner
IRB-ready pilot cohort, equity consideration, named attribution. Limited to 8 partners.
Equity
+ dispensing margin
📦
Bulk pricing · 35–48% margins

Clinical partner wholesale pricing scales with volume. All tiers deliver 35–48% gross margin per unit dispensed.

🔄
Enhancer recurring revenue

Dispensed enhancer packs (salts, botanicals, emollients) create ongoing refill revenue independent of hardware restocking.

🏷️
Co-branded materials included

Core tier and above receive co-branded patient handouts, condition-specific protocol cards, and digital assets at no added cost.

🔬
Research attribution credit

Clinical and Founder partners receive named attribution in NM Thera publications and the SOKY Commons evidence library.

12-Month Revenue Projection — Core Partner (15 units/mo)
Cumulative estimated dispensing margin · Hardware + Enhancer revenue combined
$0 $8K $16K $24K $25.2K Jan Mar May Jul Sep Nov Hardware margin Enhancer margin

35% wholesale margin, 15 units/month + 2.2× enhancer attach rate. Illustrative only.

Non-Financial Value to Your Practice
  • Improved patient outcomes and reduced re-visit frequency through better home compliance
  • Named attribution in SOKY Commons as a contributing clinical partner and evidence source
  • Practice visibility via NM Thera clinical partner directory and platform marketing
  • Research co-authorship opportunities and IRB-ready pilot design support (Clinical tier+)

NM Thera is building the SOKY Commons — an open, governed library of protocols, formulations, and clinical evidence that compounds with every contributing practitioner.

Phase 0 · Open Now
Protocol Contribution Program

Submit condition-specific immersion protocols to the SOKY Commons. All submissions are versioned, attributed by name and credential, and reviewed by the clinical advisory panel before publication.

Phase 1 · 2026–27
Clinician Pilot Cohort

Founding clinical partners participate in a structured observational cohort — collecting patient-reported outcomes, adherence data, and condition-specific response metrics. IRB-ready study design provided.

Phase 2 · 2027+
Targeted RCT Partnerships

Formal RCT design for hyperhidrosis, atopic dermatitis, and post-surgical hand rehabilitation. Seeking academic medical centre and teaching hospital partners. Full statistical design and IRB support provided.

Ongoing
Formulation Co-Development

Collaborate on condition-specific enhancer formulations with named attribution on all commercial enhancer packs and open formulation library entries.

Clinical Partner Attribution Tiers

Your contribution is recognized and made durable — in the platform, in publications, and in commercial products.

Founder

Named co-author on peer-reviewed submissions · Equity consideration · Advisory board seat · Product attribution on all dispensed materials

Clinical

Contributing clinician credit in Commons · Protocol attribution · Practice directory listing · Clinical partner badge · Early data access

Core

Protocol submission credit · Practice listing · Co-branded materials · Partner newsletter · Priority access to new SKUs

Starter

Commons member profile · Protocol access · Partner welcome kit · Dispensing margin from day one

SOKY is clinically literate and safety-first. The science grounds our restraint as much as our confidence — every claim is bounded by the evidence dossier that precedes it.

💧
Occlusion & Stratum Corneum Hydration

A sealed garment creates immersion + occlusion — increasing stratum corneum hydration 300–400% and enhancing transdermal permeation of topical additives. Session length and post-soak recovery steps are engineered around maceration risk thresholds.

"Occlusion increases hydration substantially, enhancing penetration but requiring design-level time limits." — Hadgraft & Lane, Int J Pharm, 2016 [5]

🌡️
Thermal Governance — Heat as a Pharmacokinetic Dial

Warmth significantly increases transdermal flux. All heat-enabled protocol paths (Model E+) include active temperature sensing and hard engineering cutoffs. Warmth is a clinical feature; uncontrolled heat is a hazard — the platform treats these as non-negotiable distinctions.

~500 Dalton rule governs passive absorption. Active modes (electro, ultrasound) extend beyond this threshold.

Iontophoresis — Built on Demonstrated Precedent

Tap water iontophoresis for hyperhidrosis has multiple RCTs and a Cochrane-reviewed evidence base. Issued patent US 11,602,631 establishes the wearable iontophoresis mechanism. Current limits (10–20mA), time limits, and sealed electrode modules are engineering requirements — not policy preferences.

"Tap water iontophoresis remains a first-line, evidence-based treatment for palmoplantar hyperhidrosis." — JAAD Guidelines, 2022 [13]

Active temperature sensing + hard cutoffs on all heat-enabled paths
Current and time limits + sealed electrode modules for electro (Model E)
Single-patient architecture for clinical, wound, and pelvic applications
Validated disinfection protocol + infection-control SOPs for clinical contexts
O₂ > 21% requires physical isolation of electrical components (fire safety)
OTC label: non-medical language. Pro claims carry explicit compliance strings

The clinical partner program is designed to minimize administrative overhead so you can focus on patients, not paperwork.

01

Apply & Verify

Submit your practice credentials and dispensing tier preference via the application form. Verification takes 24–48 hours for licensed clinicians.

NPI or license number
Practice type & specialty
Estimated monthly volume
02

Receive Your Partner Kit

Starter sample units, condition-specific protocol cards, patient handout templates, ICD-10 reference sheet, and co-branded dispensing materials within 5 business days.

2 sample Hand SOKY units
Protocol + formulation cards
Patient education handout
03

Dispense & Reorder

Order at wholesale pricing through your partner portal. Reorder triggers automatically when stock falls below threshold. Billing monthly, net-30 for Core tier and above.

Partner portal access
Auto-reorder available
Monthly net-30 billing
04

Contribute & Grow

Submit protocols, contribute enhancer formulation feedback, and participate in observational data collection as your cohort grows. Attribution compounds with every contribution.

Commons protocol submission
Quarterly partner calls
Tier upgrade at 30+ units

SOKY is not a medical device and makes no diagnostic or therapeutic claims beyond OTC consumer language. These citations are provided for educational context.

1

Kreyden OP. Iontophoresis for palmoplantar hyperhidrosis. J Cosmetic Dermatol. 2004;3(4):211–214.

Journal of Cosmetic Dermatology · Wiley

2

BJCP. Patient adherence to home therapy protocols: a systematic review. Br J Clin Pharmacol. 2019;85(5):978–990.

BJCP · British Pharmacological Society

3

Pariser DM, Ballard A. Iontophoresis for localized hyperhidrosis — a meta-analysis. Arch Dermatol Res. 2019;311:289–299.

Arch Dermatol Res · Springer

4

Verhagen AP et al. Balneotherapy for rheumatoid arthritis. Cochrane Database Syst Rev. 2019;(4):CD000518.

Cochrane Database · Cochrane Collaboration

5

Hadgraft J, Lane ME. Passive transdermal drug delivery systems. Int J Pharmaceutics. 2016;514(1):516–529.

International Journal of Pharmaceutics · Elsevier

6

Higgins TR, Greene DA, Baker MK. Effects of cold water immersion and contrast water therapy. J Strength Cond Res. 2017;31(5):1443–1460.

JSCR · NSCA

7

Bakker K, Riley P. APMA Clinical Recommendations for Diabetic Foot Immersion Protocols. J Am Podiatr Med Assoc. 2021;111(1).

JAPMA · APMA

8

Proksch E et al. Bathing in a magnesium-rich Dead Sea salt solution improves skin barrier function and reduces inflammation. Int J Dermatol. 2005;44(2):151–157.

International Journal of Dermatology · Wiley

9

Vermeire E et al. Patient adherence to treatment: three decades of research. J Clin Pharm Ther. 2001;26(5):331–342.

J Clinical Pharmacy & Therapeutics · Wiley

10

Sabaté E (ed.). Adherence to Long-Term Therapies: Evidence for Action. World Health Organization. 2003.

WHO · World Health Organization

11

DiMatteo MR. Variations in patients' adherence to medical recommendations. Med Care. 2004;42(3):200–209.

Medical Care · Lippincott Williams & Wilkins

12

Horne R et al. Supporting adherence to medicines for long-term conditions. Patient Preference and Adherence. 2019;13:1899–1907.

Patient Preference & Adherence · Dove Medical Press

13

Glaser DA et al. Updated guidelines on the management of primary focal hyperhidrosis. JAAD. 2022;87(4):765–777.

JAAD · American Academy of Dermatology

14

NM Thera. Pressure-Enhanced Sealing Garments for Mobile Liquid and Gas-Based Therapy. NM Thera Technologies, LLC. Filed December 2025.

US Patent & Trademark Office · Filed Dec 2025

Clinical Disclaimer

SOKY is an OTC consumer product. It is not intended to diagnose, treat, cure, or prevent any disease or medical condition. All evidence citations are for educational context only. Clinical and electro modes require practitioner oversight. This page is intended for licensed healthcare professionals considering the NM Thera clinical partner dispensing program.

NM
Thera

NM Therapeutics, Inc. · Clinical Partner Program 2026 · nmthera.com · NMT_SOKY_001
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